Monaco's unbeaten start to the season in France came to an end on Wednesday as they were knocked out of the League Cup, going down 1-0 at Reims.
A first-half goal by midfielder Antoine Devaux saw the principality club lose for the first time in any game since early May as they exited the League Cup at the first hurdle.
However, Monaco coach Claudio Ranieri had made as many as nine changes to the team that beat Lyon in Ligue 1 on Sunday, with the suspended Radamel Falcao among those missing.
This weekend, Monaco travel to face Lille in Ligue 1 in a meeting of the two sides immediately behind Paris Saint-Germain at the top of the table.
Lille have not lost or conceded a goal in their last six league games, although they were also knocked out of the League Cup this midweek, losing 1-0 at home after extra-time to second-tier Auxerre on Tuesday.
Other top-flight sides to progress this midweek were Evian, Sochaux, Bastia, Toulouse, Nantes and Rennes.
The 10 winners from this round will join France's six European representatives, who all received byes, in the draw for the last 16 of the much-maligned competition.