Southampton's reward for beating League One rivals Charlton is a home game against in-form Norwich. The Canaries beat Swindon in a shoot-out on Tuesday.
The final game sees League Two strugglers Hereford entertain MK Dons at Edgar Street. The Bulls scraped past Leyton Orient in midweek while The Dons overcame Northampton.
Johnstone Paint semi-final draw:
Carlisle v Bradford;
Leeds v Accrington.
Southampton v Norwich;
Hereford v Milton Keynes Dons.
Ties to be played the week commencing 14 December.