MK Dons manager Karl Robinson could hand Angelo Balanta a start against Southampton.
The on-loan QPR striker made his return to first-team action as a substitute in the 1-1 draw with Walsall last week after being sidelined since November with an ankle injury, and is pushing for a starting place.
Fellow loanee Keanu Marsh-Brown has returned to fitness following a groin injury but is likely to have to settle for a place on the bench.
Midfielder Adam Clayton, who has joined the Dons on loan from Leeds until the end of the season, was an un-used substitute against the Saddlers and will be hoping to make his debut against Saints.
Luke Chadwick, fresh from signing a new two-year contract at stadium:mk this week, should continue in midfield as the Dons look to continue their push for promotion at St Mary`s.