Midfielder Abdou has yet to recover from the hip injury which has kept him out of the last three games and striker Morison, the Lions' £130,000 summer signing from Stevenage, is out with a hamstring strain.
They join long-term absentees Zak Whitbread (hip), Paul Robinson (metatarsal), Pat O'Connor (cruciate) and Danny Senda (Achilles) on the sidelines for the eagerly-anticipated clash.
Winger Chris Hackett has been struggling with groin trouble but came off the bench during Friday night's goalless draw at Southend and should be available again.
"It's a massive game and one we are looking forward to," said Millwall manager Kenny Jackett.
"We've earned it, it's fantastic to go and play a Premier League team and if we get things right and play above our level then you never know."