Manager Gareth Southgate accepts that his Middlesbrough side face a must-win game at Newcastle United next Monday.
A 2-0 home defeat at the hands of champions Manchester United left Boro still three points adrift of safety with just three games left to play.
Southgate said: "We have to go to Newcastle now and deal with the atmosphere there.
"For us, in some respects, it is possibly the last throw of the dice because we need the momentum of a win there to carry into the last couple of games.
"The reality is, as I have said for a number of weeks, that we have to go to Newcastle and win.
"As a group of players and staff, we have to consign today to history.
"The last two weeks, we have been looking for a miracle, really, to get a result against the two teams we have been up against.
"Now we have realistic opportunities and we have to take them. We have got it all to do, but we have known that from probably ten weeks ago."