Manchester City winger Shaun Wright-Phillips has become the latest player to be ruled out of England's two World Cup qualifiers in June through injury.Wright-Phillips, 27, has missed the last six weeks with a knee problem and suffered a reaction when he returned to training this week.
England coach Fabio Capello is already without Portsmouth keeper David James and Middlesbrough's Stewart Downing.
They face Kazakhstan on Saturday 6 June and play Andorra at home on 10 June.
Capello will name his squad for the two matches at about 2000 BST on Sunday, after the final round of Premier League matches.
Wright-Phillips was hoping to make his Man City return against Bolton at Eastlands on Sunday, but those plans have been put on hold.
"Now Shaun will have to see a specialist," said City manager Mark Hughes.
"He is not going to be available at the weekend and he may well have a wash out of his knee in the close-season that would enable him to be fit for the start of pre-season training.
"He has worked really hard trying to get fit but this problem needs to be addressed and we must look at it."
Downing, meanwhile, will miss the England games after undergoing surgery on his right foot on Friday.
The 24-year-old had a pin inserted to mend a bone broken in a tackle by Stiliyan Petrov during Saturday's 1-1 draw with Aston Villa, and is not expected to return before the start of pre-season training in July.
"Stewart is going to be out for two or three months at least," said Boro's assistant manager Malcolm Crosby.
England number one James had a shoulder operation on Wednesday that will prevent him from adding to his 48 caps.
James has started every game under Capello, and with Ben Foster and Chris Kirkland also injured, West Ham's Robert Green appears to be the favourite to fill in for the Pompey stopper.
"One thing I've learned about the manager is that he does not take any notice of anyone else, he is his own man," said Green.
"But I will be turning up - assuming I am picked - and will prepare to play, as I do every time."
Manchester City's 22-year-old defender Nedum Onuoha is being tipped for his first call-up to the senior squad, after a host of appearances for the Under-21s.