Arsenal's late goals against Wigan make this a particularly bad result for United. Bolton were heroic in defence but the away side were made to pay for a poor first half display - how they missed the rested Ronaldo.
Full time
It's all over! A famous win for Bolton give Gary Megson his first three points as Trotters boss. United couldn't force an equaliser despite dominating the second half.
90
Is this the last chance? Hargreaves lines up a free-kick from 25 yards but shoots over.
90
Chaotic finish as Evra shoots high and wide. United get it back and are camped in Bolton's defensive third.
90
Campo miscues a header to concede a corner. Van der Sar is in the box and has to retreat as Bolton clear.
90
Four minutes of injury time have been signalled. Gary Megson is not impressed!
89
Nicolas Anelka breaks but tries to shoot rather than finding the unmarked El Hadji Diouf.
88
Substitution
John O'Shea replaces Wes Brown.
87
Yellow Card
Nicky Hunt is cautioned for time-wasting.
85
Two successive corners for United come to nothing.
83
Substitution
Home captain Kevin Nolan is replaced by Gavin McCann.
82
Bolton are closing in on their second league win of the season, although they are struggling to get out their half.
80
Louis Saha is slipped through by Carlos Tevez but is denied by the onrushing Jussi Jaaskelainen.
77
High-tempo stuff from United. Bolton are struggling to clear but Anderson can't find the target from Ferdiand's flick-on.
75
Substitution
Danny Guthrie is replaced by Christian Wilhelmsson as Megson tries to give his under-pressure team an outlet.
74
Evra crosses for Tevez at the near post who manages to miss at the far post, despite being only two yards out. Terrible miss from Tevez!
72
Substitution
Gary Megson responds to United's change by bringing on Gary Speed for Kevin Davies.
71
Luis Carlos Nani shoots wide of the near post from 25 yards.
69
Louis Saha glances a header wide as United continue to dominate. Bolton cannot retain possession.
67
The away side increase the pressure with a succession of corners that Bolton survive.
65
Yellow Card
Kevin Nolan carded for catching Patrice Evra. Jussi Jaaskelainen tips over Hargreaves' shot - United's best effort so far.
62
Sir Alex Ferguson is making his decisions from the stands after apparently being dismissed from the dugout. United are playing with three at the back.
60
Substitution
Midfielder Luis de Abreu Anderson replaces centre-half Gerard Pique.
58
Bolton break quickly after United give the ball away. Ricardo Gardner flies down the left-wing but his cross-shot goes easily wide.
56
Michael Carrick drags a shot wide under pressure from Danny Guthrie.
54
Bolton are gaining in confidence with Campo taking charge of midfield. Evra cuts out his through-ball to Davies.
52
Danny Guthrie is baulked by Michael Carrick on the edge of the United area and the home side have a free-kick in a dangerous area. Anelka's shot is deflected over the bar.
50
Owen Hargreaves can only find touch with a simple pass. Despite showing more urgency United have yet to threaten.
48
Nicolas Anelka shoots over after a quick break from the home side.
Second half
No changes from either manager at the start of the second half. Chris Eagles and Darren Fletcher are the attacking players on the United bench.
Half time
The referee blows for half-time. United have been lacklustre - will Sir Alex Ferguson make changes?
45
Evra extremely lucky to avoid a booking for another foul on Davies.
43
Tevez nearly latches onto a long clearance but Jaaskelainen collects.
41
Gary Megson will be delighted with his team's work-rate. United just can't settle.
39
Classic United counter-attack ends with Hargreaves slicing a left-footed shot wide.
38
More pressure from Bolton as the rain comes down. Campo's free-kick is cleared.
36
Nicky Hunt tries his luck and another deflected shot flies wide of Van der Sar's post. United clear the corner.
34
Left-footed shot by Danny Guthrie is deflected wide. Van der Sar claims the corner.
32
United clear the free-kick, with Kevin Davies receiving another lecture for a robust challenge on Evra. These two are having a private battle and Davies in particular must be careful.
31
Theatrics from Campo under Tevez's challenge earns a free-kick.
29
Easy save by Jussi Jaaskelainen from Tevez's deflected shot.
27
This is turning into a stop-start encounter with little quality passing.
22
Evra is ok but United waste the free-kick. El Hadji Diouf catches Nani, who stays down to jeers from the home crowd.
21
Yellow Card
Davies does go into Mark Clattenburg's book this time; a poorly timed slide into Evra leaves the Frenchman needing treatment.
19
Flare-up between Kevin Davies and Patrice Evra. Again no booking. The visitors haven't properly settled yet.
16
Abdoulaye Meite clatters into Tevez. Just a talking to for the big defender.
14
Corner to Bolton after good work from Ricardo Gardner. Edwin Van der Sar collects easily.
11
Louis Saha shoots high and wide as United exert immediate pressure after conceding.
9
Goal
Nicolas ANELKA scores on his return! Gerard Pique failed to clear Campo's long free kick and ANELKA made no mistake. Bolton 1-0 Man Utd.
7
Danny Guthrie has a shot blocked on the edge of the area.
5
Luis Carlos Nani crosses dangerously but Ryan Giggs can't make contact.
2
Ramos Ivan Campo makes no contact with a volley from the edge of the area. High-tempo start from the home side.
Kickoff
We're underway with Bolton looking for their first home win against United since 1978.
The sun has made an unexpected appearance at the Reebok Stadium.
The injured Wayne Rooney scored a hat-trick in his team's 4-0 win in the corresponding fixture last season.
United have scored four goals in three of their last four meetings with the Trotters.
Gerard Pique comes in for the injured Nemanja Vidic; Cristiano Ronaldo, scorer of 10 goals in his last 11 appearances, is rested.
Danny Guthrie is preferred to Gary Speed whilst Nicolas Anelka and El Hadji Diouf return in attack.
Manchester United line-up: Van der Sar, Brown, Pique, Ferdinand, Evra, Nani, Carrick, Hargreaves, Giggs, Saha, Tevez
Bolton Wanderers
Manchester United
Arsenal's late goals against Wigan make this a particularly bad result for United. Bolton were heroic in defence but the away side were made to pay for a poor first half display - how they missed the rested Ronaldo.
Full time
It's all over! A famous win for Bolton give Gary Megson his first three points as Trotters boss. United couldn't force an equaliser despite dominating the second half.
Is this the last chance? Hargreaves lines up a free-kick from 25 yards but shoots over.
Chaotic finish as Evra shoots high and wide. United get it back and are camped in Bolton's defensive third.
Campo miscues a header to concede a corner. Van der Sar is in the box and has to retreat as Bolton clear.
Four minutes of injury time have been signalled. Gary Megson is not impressed!
Nicolas Anelka breaks but tries to shoot rather than finding the unmarked El Hadji Diouf.
Substitution
John O'Shea replaces Wes Brown.
Yellow Card
Nicky Hunt is cautioned for time-wasting.
Two successive corners for United come to nothing.
Substitution
Home captain Kevin Nolan is replaced by Gavin McCann.
Bolton are closing in on their second league win of the season, although they are struggling to get out their half.
Louis Saha is slipped through by Carlos Tevez but is denied by the onrushing Jussi Jaaskelainen.
High-tempo stuff from United. Bolton are struggling to clear but Anderson can't find the target from Ferdiand's flick-on.
Substitution
Danny Guthrie is replaced by Christian Wilhelmsson as Megson tries to give his under-pressure team an outlet.
Evra crosses for Tevez at the near post who manages to miss at the far post, despite being only two yards out. Terrible miss from Tevez!
Substitution
Gary Megson responds to United's change by bringing on Gary Speed for Kevin Davies.
Luis Carlos Nani shoots wide of the near post from 25 yards.
Louis Saha glances a header wide as United continue to dominate. Bolton cannot retain possession.
The away side increase the pressure with a succession of corners that Bolton survive.
Yellow Card
Kevin Nolan carded for catching Patrice Evra. Jussi Jaaskelainen tips over Hargreaves' shot - United's best effort so far.
Sir Alex Ferguson is making his decisions from the stands after apparently being dismissed from the dugout. United are playing with three at the back.
Substitution
Midfielder Luis de Abreu Anderson replaces centre-half Gerard Pique.
Bolton break quickly after United give the ball away. Ricardo Gardner flies down the left-wing but his cross-shot goes easily wide.
Michael Carrick drags a shot wide under pressure from Danny Guthrie.
Bolton are gaining in confidence with Campo taking charge of midfield. Evra cuts out his through-ball to Davies.
Danny Guthrie is baulked by Michael Carrick on the edge of the United area and the home side have a free-kick in a dangerous area. Anelka's shot is deflected over the bar.
Owen Hargreaves can only find touch with a simple pass. Despite showing more urgency United have yet to threaten.
Nicolas Anelka shoots over after a quick break from the home side.
Second half
No changes from either manager at the start of the second half. Chris Eagles and Darren Fletcher are the attacking players on the United bench.
Half time
The referee blows for half-time. United have been lacklustre - will Sir Alex Ferguson make changes?
Evra extremely lucky to avoid a booking for another foul on Davies.
Tevez nearly latches onto a long clearance but Jaaskelainen collects.
Gary Megson will be delighted with his team's work-rate. United just can't settle.
Classic United counter-attack ends with Hargreaves slicing a left-footed shot wide.
More pressure from Bolton as the rain comes down. Campo's free-kick is cleared.
Nicky Hunt tries his luck and another deflected shot flies wide of Van der Sar's post. United clear the corner.
Left-footed shot by Danny Guthrie is deflected wide. Van der Sar claims the corner.
United clear the free-kick, with Kevin Davies receiving another lecture for a robust challenge on Evra. These two are having a private battle and Davies in particular must be careful.
Theatrics from Campo under Tevez's challenge earns a free-kick.
Easy save by Jussi Jaaskelainen from Tevez's deflected shot.
This is turning into a stop-start encounter with little quality passing.
Evra is ok but United waste the free-kick. El Hadji Diouf catches Nani, who stays down to jeers from the home crowd.
Yellow Card
Davies does go into Mark Clattenburg's book this time; a poorly timed slide into Evra leaves the Frenchman needing treatment.
Flare-up between Kevin Davies and Patrice Evra. Again no booking. The visitors haven't properly settled yet.
Abdoulaye Meite clatters into Tevez. Just a talking to for the big defender.
Corner to Bolton after good work from Ricardo Gardner. Edwin Van der Sar collects easily.
Louis Saha shoots high and wide as United exert immediate pressure after conceding.
Goal
Nicolas ANELKA scores on his return! Gerard Pique failed to clear Campo's long free kick and ANELKA made no mistake. Bolton 1-0 Man Utd.
Danny Guthrie has a shot blocked on the edge of the area.
Luis Carlos Nani crosses dangerously but Ryan Giggs can't make contact.
Ramos Ivan Campo makes no contact with a volley from the edge of the area. High-tempo start from the home side.
Kickoff
We're underway with Bolton looking for their first home win against United since 1978.
The sun has made an unexpected appearance at the Reebok Stadium.
The injured Wayne Rooney scored a hat-trick in his team's 4-0 win in the corresponding fixture last season.
United have scored four goals in three of their last four meetings with the Trotters.
Gerard Pique comes in for the injured Nemanja Vidic; Cristiano Ronaldo, scorer of 10 goals in his last 11 appearances, is rested.
Danny Guthrie is preferred to Gary Speed whilst Nicolas Anelka and El Hadji Diouf return in attack.
Manchester United line-up: Van der Sar, Brown, Pique, Ferdinand, Evra, Nani, Carrick, Hargreaves, Giggs, Saha, Tevez
Bolton Wanderers line-up: Jaaskelainen, Hunt, O'Brien, Meite, Gardner, Campo, Nolan, Guthrie, Davies, Anelka, Diouf