Southend manager Paul Sturrock has injury doubts ahead of the game against Wycombe.
Defender Bilel Mohsni limped off late on in the Shrimpers' 2-0 win over Cheltenham on Tuesday and is a major doubt, as is on-loan midfielder Josh Simpson who left the field at half-time with an ankle injury.
Fellow midfielder Anthony Grant picked up a back injury and could miss the visit of the Chairboys while defender Peter Gilbert is unavailable as he completes his three-match ban.
A sickness bug is sweeping through Sturrock's squad with defender Chris Barker, midfielder Ryan Hall and goalkeeper Rhys Evans all suffering during the week.
On-loan striker Antonio German has returned to QPR while Jack Midson will continue up front after his brace in midweek and Jonny Herd is likely to keep his place at left-back.
Wycombe are likely to field an unchanged line-up from the side that beat Bury.
Defender Leon Johnson will make his 100th start for Gary Waddock's men, against the club that first signed him as a trainee.
Striker Jon-Paul Pittman continues his recovery from a ruptured knee tendon which is expected to keep him out until the new year.
Josh Parker (foot) remains the only other long-term injury concern and the midfielder will not feature for at least six weeks.
Midfield Lewis Montrose is suspended so on-loan Rushden playmaker Stewart Lewis could take his place in the centre of the park.
Wanderers have scored in their last 12 league games and the hero from the 1-0 victory at Bury, striker Scott Rendell, will be the key to continuing the positive trend.