East Stirling captain Kevin Turner will be fit enough to start the opening game of the Third Division season against Queens Park.
Striker Michael Herd, who has found the net three times already this campaign, will feature after recovering from a knee injury.
However, summer signing Craig Donaldson remains out with an ankle knock.
Manager John Coughlin, whose finished bottom of the Scottish Football League last season, said: "It is a new season and a new squad of players and we are optimistic that we can compete a lot better this time out.
"Queens Park are a good side but we competed well with them last season in our home games. But one thing we have to do is defend set-pieces better than we did when we lost 5-0 to Morton last Sunday."
David Anderson is an injury doubt for Queens Park.
Midfielder Anderson is nursing a calf problem and will continue to be assessed up until kick-off.
The Spiders, who have made the top-four and the play-offs for the past three seasons, are looking to build on a fine Scottish Communities League Cup win over Airdrie last Saturday.
Hampden head coach Gardner Speirs said: "We want to keep the positivity going but it will not be easy as, whilst we want to start the season well, East Stirling will be just as determined.
"They pushed us really hard in the games on their own patch last season and look to have improved their squad, so we need to play at a high standard as soon as that first whistle goes."