Cheltenham will be without defender Troy Brown when they welcome Wycombe.
The centre-back tore ankle ligaments in their 1-0 defeat to Bristol Rovers on Tuesday night and is now set to spend up to four weeks on the sidelines meaning manager Mark Yates will be forced into a change against the Chairboys.
Brown's withdrawal shortly after half-time against the Pirates saw right-back Sido Jombati sent on with Wolves loanee Michael Ihiekwe partnering Steve Elliott at the heart of the defence and Yates may stick with that set-up from the start.
He could also be boosted by the return of midfielder David Noble, yet to feature in 2014 due to a troublesome hamstring problem, with the Rotherham loanee hopeful of returning to full training in the build-up to kick-off.
Wycombe will assess striker Dean Morgan.
The former Luton forward was forced off during the first half of their 1-1 draw with Fleetwood on Tuesday after his hamstring problem flared up in only his second game since returning from injury.
Meanwhile, Jon-Paul Pittman could be involved against the Robins having resumed full training over a week ago and manager Gareth Ainsworth confirmed he is in his thoughts ahead of the clash.
Ainsworth's Blues sit just two points above the relegation zone having failed to pick up three points since December 21, a run of nine matches.