Berwick will be without Dene Droudge, Marc Lancaster and Damien Gielty when they host Stirling.
Droudge is out for the long term with a knee problem and Lancaster has a back injury, while Gielty will be absent due to work commitments.
Winger Ross Gray will play the last game of his loan spell from Livingston and manager Ian Little is hoping that the 21-year-old will bow out in style.
He said: "Ross has been terrific for us and we would really have liked to keep him but Livingston want him back. Hopefully he can give us another fine performance in his final game.
"Our pride was hurt when we lost six goals to Stirling in our last meeting and we will be looking to put that right in this meeting."
Goalkeeper David Crawford will be included in the Stirling squad.
The new signing will be part of the travelling party looking to repeat the 6-3 success over the Shielfield men in their last meeting.
Missing for Greig McDonald's bottom-of-the-table side is the suspended Gary Thom, Jamie Clark (illness) and Gavin McPherson, who has opted to leave the club, but Ross McGeachie should shake off a knock.
McDonald said: "We certainly enjoyed the result the last time we played Berwick and a repeat of that would be fantastic.
"We have not won away from home this season so it would be good to put that right as we are determined to get away from the position we are in."