Manchester United will face Everton in the FA Cup semi-finals, while Chelsea lie in wait for the winners of the sixth round meeting of Arsenal and Hull City.
United romped through to the last four with a dominant 4-0 victory over Premier League rivals Fulham at Craven Cottage, with Carlos Tevez scoring twice and Wayne Rooney and Ji-sung Park also finding the net.
Everton recovered a from a goal behind to beat Middlesbrough 2-1 at Goodison Park on Sunday afternoon, with Marouane Fellaini and Louis Saha scoring the goals for David Moyes' side.
Guus Hiddink's Chelsea eased into the semi-finals by winning 2-0 at Coventry City, with Didier Drogba and Alex their goalscorers at the Ricoh Arena.
The Gunners set up a sixth round meeting with Hull City by beating Burnley 3-0 in a delayed fifth round replay on Sunday.
Arsenal or Hull City v Chelsea
Manchester United v Everton
Ties to be played weekend of April 18 and 19.