Manchester United captain Rio Ferdinand is a doubt for the second leg of the Champions League knockout round tie against Internazionale.
The England centre-half was replaced at half-time of the 4-0 FA Cup sixth round victory at Fulham and is facing a race to be fit for the midweek action.
Red Devils boss Sir Alex Ferguson admitted: "Rio Ferdinand is a bit of a concern.
"He went over on his ankle and I hope he is alright for Wednesday, because he is so important to us."
Ferguson may also have problems at right-back, with John O'Shea suffering a suspected hamstring problem against the Cottagers, while Gary Neville, Wes Brown and Rafael da Silva are all still sidelined.
However, Inter have problems of their own for the trip to Old Trafford, with the tie goalless following the first leg in the San Siro.
Inter coach Jose has four central defenders ruled out through injury, with Marco Materazzi, Nicolas Burdisso, Cristian Chivu and Walter Samuel all unlikely to feature.