Manchester United central defender Rio Ferdinand is set to be sidelined for around two weeks due to a thigh injury.
The 30-year-old England international was forced to miss the season-opening 1-0 win over Birmingham City at Old Trafford, with manager Sir Alex Ferguson confirming a new injury setback.
He said: "I would imagine Rio will be out for two weeks."
Ferdinand is now an early doubt for England's World Cup qualifier against Croatia on September 9.
After the win over the Blues, which came courtesy of a Wayne Rooney strike, Ferguson spoke of is confidence that his side can cope with the absence of Cristiano Ronaldo over the coming months.
He added: "I know some of our supporters are still worried that I have not bought a megastar to replace Cristiano.
"They are concerned because they can't quite work out how we are going to compensate for all the goals Cristiano used to get for us.
"But I am more than happy with our squad and although we have lost a major player, I believe we are on the threshold of a very exciting era for Manchester United."