Manchester United will be without the services of Louis Saha as they bid to reach the semi-finals of the Champions League by clawing back a 2-1 first leg deficit against AS Roma.
The French striker came on as a substitute in last week's loss in the Italian capital after being sidelined for a month with a hamstring problem, but will not be risked in the second leg at Old Trafford.
United boss Sir Alex Ferguson confirmed: "He's not fit. He felt his hamstring was a bit tight in training on Friday in Rome. Therefore, we have to be on the cautious side.
"There's no point in bringing somebody back who is not 100 per cent fit and then them suffering further injury. Maybe he will be fit for Saturday's cup tie against Watford, but not for the Roma game.
"But the good thing is that we came out of Saturday's game (the defeat at Portsmouth) without any more injuries.
"For, Tuesday, obviously Paul Scholes won't be available [due to suspension] so we'll have to make a decision about that one.
"We do recover [from defeats], and usually we recover well. This club has always been that way. We lost to Arsenal in October and went on a long run, and the same happened when we lost to West Ham and Arsenal again.
"This club is made like that. Losing a game is not an unusual factor in football. Everyone loses at some point. It's what you do about it that makes a team, and I'm confident about that side of things."