Liverpool, Arsenal, Chelsea and holders Manchester United will discover their quarter-final opponents in the draw for the latter stages of the Champions League this morning.
The four Premier League sides could face a combination of each other or a quartet of other clubs from across Europe when the open draw is made in Nyon, Switzerland at 11am.
Spanish champions Barcelona, Bayern Munich of the Bundesliga, Portuguese side FC Porto and Villarreal of Spain are the other teams in the hat.
The first legs will be played on April 7 and 8, while the return legs will be staged on April 14 and 15.
The draw will also reveal the potential semi-final opponents of each side should they progress from the last eight.
United, who beat Chelsea on penalties in last year's final in Moscow, are joint favourites to defend their crown with Barcelona.
However, winger Cristiano Ronaldo is hoping the reigning champions are not drawn against Bayern Munich following their 12-1 aggregate demolition of Sporting Lisbon in the last round.
"Bayern Munich are very strong," said Ronaldo. "I watched them play against my old team, Sporting Lisbon, and I was very sad because I didn't expect Sporting to lose so heavily.
"But this can happen in football. Bayern are very good. They have mature players, strong players and quick players. Franck Ribery and Miroslav Klose are very impressive.
"Bayern play like a team and they look very difficult to beat."
Meanwhile, Liverpool captain Steven Gerrard insist his side fears no-one following their impressive victory over Real Madrid in the last round.
"We're not running scared of anyone," he claimed. "We'll take who we get and believe that we're going to go through.
"If we could hand-pick an opponent then maybe we'd want someone like Villarreal or Porto but at this stage of the competition there are no easy games.
"Everyone who's got to this stage of the competition has done well. They'll all believe in themselves.
"But we've shown - the players, the manager and the fans - that we're a force to be reckoned with when we pull it all together."