Manchester United have revealed that Michael Carrick will be sidelined for up to six weeks after suffering a fractured right elbow.
The 26-year-old midfielder picked up the injury during the latter stages of Tuesday's 1-0 Champions League victory over AS Roma at Old Trafford.
"Michael has sustained a fractured right elbow and will be out for up to six weeks," confirmed a United spokesman.
The news of Carrick's injury comes as a blow to both club and country.
United boss Sir Alex Ferguson now has a midfield selection headache for Saturday's Premier League meeting with Wigan Athletic as both Owen Hargreaves (knee) and Darren Fletcher (leg) had already been ruled out.
Hargreaves will be sidelined for around four weeks with tendonitis problems in his knee, while Fletcher continues to be troubled by an injury picked up in early September.
Meanwhile, the timescale on Carrick's recovery also rules him out of England two vital Euro 2008 qualifiers later this month.
The former West Ham United and Tottenham midfielder will now play no part in either match against Estonia and Russia.