Goalkeeper Joe Hart has been ruled out of England's friendly against France due to a back injury sustained during training on Tuesday.
The 23-year-old Manchester City player had been expected to win his eighth cap against Les Bleus at Wembley, but he has now returned to his club after being assessed by the England medical staff.
Watford's Scott Loach has joined up with the senior squad as cover, having played for the Under-21s in their 2-0 defeat by Germany on Tuesday evening.
Meanwhile, Citizens back-up keeper Shay Given has hinted that he will seek to leave the club in the January transfer window after losing his first-team spot to Hart.
He told the club's official website: "My own personal situation isn't ideal. We'll see what happens over the next couple of months.
"You try and work hard in training, but obviously it's difficult to try and re-enact a match situation.
"I wish I was playing more because I would feel sharper, but this is the situation I'm in and I can't really change that."