Manchester United must beat Stoke at Old Trafford and hope the Blues slip up at home to Roberto Martinez's side if they are to land a fourth successive title.
Given Chelsea's home form, it's a thin hope for United. But Ferguson is backing Wigan to give their all.
"It's pointless going into the game expecting anything from Chelsea in our favour," said Ferguson.
"I have confidence that Wigan will do their best and they will try.
"There's pressure on both us and Chelsea because we both need to win but I don't know what's going on in Chelsea's minds - all I know is that in this situation we just hope."
Ferguson will be without Antonio Valencia, who has been ruled out with an ankle injury, but Rio Ferdinand is expected to return.
"In a way the situation helps us because we can express ourselves, like we did against Sunderland.
"The players enjoyed themselves and we could have won very comfortably and scored four or five.
"We played without nerves, which is down to our experience. We have been here before and it's not affected us."
With the 2010 title still up grabs, Ferguson was already looking forward to next season.
"The Premier League will be more competitive next season," said Ferguson.
"This is the best Tottenham team I have experienced in terms of substance and City will be strong again next season. It is a strong league."