The Frenchman sustained an ankle injury in last weekend's victory over Aston Villa, but was deemed fit enough to take part in Tuesday's home defeat to Wolves.
However, the injury has not improved and he is a doubt for the United clash.
Provisional squad: Kirkland, Melchiot, Figueroa, Edman, Boyce, Bramble, Thomas, Scharner, Brown, N'Zogbia, Koumas, Watson, Cho, Gomez, Sinclair, Scotland, King, McCarthy, Rodallega, Pollitt.
Fitness fight: N'Zogbia is struggling to make the visit of the champions
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