Rooney has missed two games since injuring his ankle against West Bromwich on New Year's Day.
However, the England forward has trained this week and is contention to make the journey to White Hart Lane.
'He is training and he should be fit for Sunday,' said Ferguson.
Big lift: United striker Rooney is set to return to the starting XI for his side's clash with Spurs at White Hart Lane
Skipper Nemanja Vidic is also expected to be fit after sitting out last Sunday's FA Cup triumph over Liverpool, while veteran keeper Edwin van der Sar is a 'possible' according to Ferguson after missing three games with a virus.
Meanwhile, the United boss confirmed no talks had taken place with Ryan Giggs over another contract extension for next season.
However, given the Scot's assessment of Giggs' performance against Liverpool at Old Trafford, it seems certain the winger will be granted another 12 months.
'Ryan is an incredible human being,' said Ferguson. 'He defies the logic of forwards when he plays at the level he did last Sunday.
Old head: But Giggs (left) has been playing like a man half his age for Manchester United this season
'Obviously we know how to manage him. He doesn't play every week but he makes a contribution that lifts the team. He did that in the second half last week. He was outstanding.
'His fitness was fantastic. He kept going for the whole 90 minutes. He has been doing that for two decades.
'No other player has ever done that - or is ever likely to. He is quite an amazing man.'
Thatwill be welcome news for the 37-year-old, who, having ruled out aninternational comeback, is keen to extend his club career for as longas possible.
'I am feelinggood and as long as I am feeling good and still enjoying it, I willcarry on playing,' he told the Manchester Evening News. 'As long as theclub wants me as well, I will.'
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