United will be looking for maximum points because Man City lost at Everton earlier today, a win for the Reds will give them a 15 point lead over Mancini's dreamers.
Here are the confirmed line-ups:
Man Utd: De Gea, Smalling, Ferdinand, Vidic, Buttner, Welbeck, Giggs, Anderson, Young, Rooney, van Persie
Subs: Lindegaard, Carrick, Evans, Valencia, Hernandez, Powell, Kagawa.
Reading: Taylor, Shorey, Kelly, Pearce, Mariappa, Karacan, Leigertwood, McAnuff, McCleary, Robson-Kanu, Hunt
Subs: McCarthy, Gunter, Harte, Morrison, Akpan, Blackman, Le Fondre
Source: United Mad