The two teams regularly battle it out for the Premier League title, and this Monday they meet with Arsenal just one point clear of United at the top.
We look back at five recent classic clashes during the Fergie-Wenger years.
Best of enemies: Wenger (left) and Ferguson (right) have frequentlybeen at the centre of heated clashes between Arsenal and ManchesterUnited
Manchester United 2-1 ArsenalFA Cup semi-final replay, 14 April 1999
David Beckham put United into the lead but Dennis Bergkamp equalised in the 69th minute. Minutes later Roy Keane was sent off and in the last minute, Bergkamp had a penalty saved by Peter Schmeichel.
A man down in extra-time, Ryan Giggs raced from his half into the Arsenal box to score an incredible goal past David Seaman, helping United to an unprecedented treble. It was the Cup's last-ever semi-final replay.
Manchester United 6-1 Arsenal Premier League, 25 February 2001
United tore Arsenal apart from the start, with the usually unassuming Dwight Yorke scoring three goals in the first 22 minutes, and Thierry Henry's momentary equaliser quickly forgotten.
Roy Keane and Ole Gunnar Solskjaer added two more in the next 16 minutes and Teddy Sheringham completed Arsenal's humiliation in the last minute.
United went on to win their seventh title in nine seasons.
Manchester United 0-1 ArsenalPremier League, 8 May 2002
Arsenal sealed the double in this penultimate game of the season, taking the title from Ferguson's men at their own ground.
Paul Scholes was lucky to avoid a sending off for his challenge on Edu in a tense and aggressive first half.
Sylvain Wiltord scored for Arsenal at 58 minutes, after fellow Frenchman Fabien Barthez had blocked a shot from Freddie Ljungberg, as Wenger's men finished the season on a run of 13 unbeaten matches.
Manchester United 2-0 Arsenal Premier League, 24 October 2004
Arsenal's Invincibles headed to Old Trafford on a 49-match unbeaten run for another ferocious battle. Wayne Rooney was given a controversial penalty in the 72nd minute after a challenge from Sol Campbell and Ruud van Nistelrooy fired it home. Rooney added another soon after.
A mass row ensued after the final whistle, with food hurled between the rivals in the tunnel and a pizza hitting Ferguson in the face. The infamous incident became known as both as the 'battle of the buffet' and 'pizzagate'.
Arsenal 2-1 Manchester United Premier League, 21 January 2007
In the first match between the two clubs at the Emirates, Arsenal were barely in the title race and United were set to go nine points ahead after Wayne Rooney's diving header from Patrice Evra's cross made it 1-0.
Then seven minutes from time, Robin van Persie equalised for the Gunners and Thierry Henry headed a dramatic injury-time winner past Edwin van der Sar in the very last minute.
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