Southampton 1-2 Manchester UnitedSouthampton: Bialkowski, Butterfield,Fonte, Seaborne, Harding, Oxlade-Chamberlain, Schneiderlin, Chaplow, DoPrado, Lambert, Barnard (Dickson 73).Subs: Davis, Richardson, Martin,Gobern, Doble, N'Guessan.
Goals: Chaplow 45.Man Utd: Lindegaard, O'Shea, Evans,Smalling, Fabio Da Silva (Brown 46), Gibson (Giggs 58), Anderson (Nani 58), Scholes, Obertan,Hernandez, Owen.Subs: Kuszczak, Berbatov, Rooney, Bebe.
Goals: Owen 65.Referee: Martin Atkinson (W Yorkshire)
76min: GOAL! Southampton 1-2 MANCHESTER UNITED
'Giggs, Giggs will tear you apart again.' Dickson gives the ball away to the Welshman who feeds a perfect ball into the feet of Javier Hernandez The Mexican ends up on the floor buthis shot creeps under Bialkowski and into the corner.
75min: Chamberlain has not disappointed, he goes on another run but this time 23 yards out to goal, he drags a shot just wide.
73min: First change from the Saints as full-back Ryan Dickson replaces Barnard.
71min: Hold that it's not all one way traffic! From a corner Harding from a tight angle rockets a shot across goal that goes just wide.
68min: A few worried faces now, United are on top and you just sense this is only going to end in tears for the hosts.
65min: GOAL! Southampton 1-1 MANCHESTER UNITED
He makes up for it though! Obertan shows his first bit of skill on the night to get a cross in from the right and after it's deflected, Michael Owen sharp as a razor heads the loose ball into the bottom corner. Get that man back into the England squad!
64min: About as close as United have come. Nani sends a great ball to the near post but Owen can only steer a first time effort over the bar.
The sort of chance the 1998 version would have scored.
63min: Chaplow brings down Scholes on the left and United have a free-kick.
Giggs whips in a cross but Evans' header is weak and straight at Bialkowski.
61min: This is very unlike United. They still cannot string two passes together and this is very easy for the hosts who have played the much better football.
In a tangle: Owen (left) and Harding battle for the ball
58min: Right on cue, Giggs replaces Gibson and Nani is on for Anderson. No Rooney. No Berbatov this evening then.
56min: The big guns are getting ready. Ryan Giggs and Nani are preparing to come on.
53min: Without sounding too harsh, Gibson is just not good enough to play for United.
He fails to cut out a pass to Harding in midfield who proceeds to beat three United players before his tame shot is saved.
50min: United still look shaky at the back, and Lee Barnard just fails to find Chaplow inside the box which would have put the goal scorer in with a superb chance to double the lead.
48min: Early pressure from United at the start of this half after winning three corners.
The last one from Anderson sails over everyone's heads though and the Saints clear.
Second-half: No, wait. Wes Brown replaces Fabio which I guess is due to an injury for the latter.
18.17: As I said in the intro, Saints will be fully aware of a second-half comeback. No changes from United though by the looks of things.
18.14: From InfoStradaLive:
Four teams from outside the top two divisions have reached the last 16 of the FA Cup for the first time since 1990.
Are we heading for five?
18.12: One place I would not want to be now is in the United dressing room. Fergie looked fuming as the half-time whistle went, and no doubt he will use the same hairdryer as the one against Blackpool.
Half-time: Southampton 1-0 Manchester United
Cupset? Chaplow (30) put Southampton into the lead on the stroke of half-time
45min: GOAL! SOUTHAMPTON 1-0 Manchester United
Belter! Evans gives the ball away to Richard Chaplow on the edge of the box and the midfielder takes a couple of steps before thundering a shot past Lindegaard at his near post.
44min: Or maybe not! Danny Butterfield sends in a superb deep cross and unmarked eight yards out, Guly heads over. BIG CHANCE.
42min: This game is in dire need of a goal. the game is lowing by the minute and both sides seem content to go to half-time 0-0.
39min: United just starting to edge the possession but in way are the League one side under pressure. Fabio has been the visitors only real bright spark.
36min: Chances are few and far between but as a spectacle it's very interesting to watch.
Saints are closing down every United player and are the better side but haven't quite had the luck in the final third.
33min: Obertan finally gets into the game.but wastes a good chance. Inside the box and with a few options he has a wild lash at goal that goes quite a bit wide, very sloppy.
One to watch: Alex Oxlade-Chamberlain (right) is wanted by a host of Premier League clubsFOR EDITORIAL USE ONLY Additional licence required for any commercial/promotional use or use on TV or internet (except identical online version of newspaper) of Premier League/Football League photos. Tel DataCo +44 207 2981656. Do not alter/modify photo. (Photo credit should read ADRIAN DENNIS/AFP/Getty Images)
31min: They are sloppy in midfield too. Anderson and Gibson have been giving the ball away while the likes of Gabriel Obertan and Hernandez have hardly featured.
28min: They just seem to lack leadership do United, no Vidic or Ferdinand is really hurting them they do not look comfortable at all.
25min: Another free-kick for Saints after Darron Gibson needlessly takes away the feet of Morgan Schneiderlin.
From 30 yards Lambert drills another shot just over the bar. He does hit them with some power too.
22min: Good cup tie this, Saints are edging it and Evans takes no chances on Harding's cross, heading over his own bar.
19min: Saints win a free-kick 25 yards out but Lambert's strike is just over the bar, good effort mind.
17min: Don't think Owen intended this but he comes mighty close to putting United in front. His cross from the right lobs Bialkowski and crashes off the inside of the far post before bouncing to safety.
15min: Good hit that. A cross in the box is slightly behind Ricky Lambert but he adjusts his body well to hit a volley towards the corner.
It slightly lacks power however and Anders Lindegaard comfortably takes.
On the run: Manchester United's Anderson (left) attempts to escape the attention of Saints' Richard Chaplow
13min: Of course much of the focus will be on young Alex Oxlade-Chamberlain this evening.
He has started off fine though, no doubt aware that the spotlight is on him.
10min: Michael Owen seems to be playing in a deeper role this evening, but it has not harmed him too much, with his right foot strike from 18 yards just wide of the post.
7min: Southampton have the ball in the net but Dan Harding is ruled marginally offside inside the box. Correct call but United are under the cosh.
6min: Saints are getting stronger and a series of long balls in the box is troubling the visitors.
3min: Bright enough start from the Saints as they look to take the game towards United.
Kick-off: We are underway at St Mary's
17.10: Anders Lindegaard is handed his Manchester United debut in the FA Cup fourth-round tie against Southampton at St Mary's.
The Danish goalkeeper, who joined the Red Devils earlier in the transfer window, is one of a raft of changes made by manager Sir Alex Ferguson, with only Javier Hernandez and Jonny Evans remaining from the third-round defeat of Liverpool.
Southampton manager Nigel Adkins, meanwhile, decides to drop influential goalkeeper Kelvin Davis to the bench in favour of Bartosz Bialkowski, who started for Saints in the previous two rounds.
17.05: If Southampton will have learned anything over the last few days, it's that two goal leads are far from safe - especially against Manchester United.
United produced a stunning second half-comeback to score three times without reply in their 3-2 win at Blackpool. While earlier today Birmingham did the same against Championship side Coventry.
The Saints have been warned, here is the team news:
Southampton v Man UtdSouthampton: Bialkowski, Butterfield, Fonte, Seaborne, Harding, Oxlade-Chamberlain, Schneiderlin, Chaplow, Do Prado, Lambert, Barnard. Subs: Davis, Richardson, Dickson, Martin, Gobern, Doble, N'Guessan.Man Utd: Lindegaard, O'Shea, Evans, Smalling, Fabio Da Silva, Gibson, Anderson, Scholes, Obertan, Hernandez, Owen. Subs: Kuszczak, Brown, Berbatov, Rooney, Giggs, Nani, Bebe.Referee: Martin Atkinson (W Yorkshire)
Mexican magic: Javier Hernandez will look to build on his impressive display at Blackpool
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Explore more:People: Bebe, Fabio Da Silva, Nani, Martin Atkinson, Alex Ferguson, Michael Owen, Nigel Adkins, Gabriel Obertan, Wes Brown, Ryan Giggs Places: Birmingham, Liverpool, United Kingdom