Porto dumped United out of the last 16 stage in 2004 with a last-minute goal at Old Trafford and Ferdinand is relishing the prospect of getting revenge.
"We have unfinished business with Porto," he told the Daily Mirror.
"I'm excited about the game and looking forward to it.
"It's a decent draw but at this stage of the tournament whoever you play is going to be difficult. I'm please we have avoided the English teams.
Focused"Emotionally and physically it would have been draining because there's so much that goes on with playing English sides.
"We know that from playing Chelsea last season. But we don't look too far ahead at the semi-finals.
"We're just focused on the quarter-final and won't disrespect Porto by looking at who we can play in the next round."
The England centre-back also feels the Red Devils have firmly placed last week's 4-1 defeat by Liverpool to the back of their minds to focus on the next Premier League clash with Fulham.
"It's out of our system. We've trained well and had four good, solid days getting ready for Fulham," he added.