The England defender has been troubled by a succession of problems for the past three seasons now.
He was making only his 26th appearance of the season when he turned out in Sunday's 1-0 defeat at Arsenal on Sunday, compared to the 43 that have been amassed by central defensive partner Nemanja Vidic.
Raring to go: Central defender Rio Ferdinand is determined to finish Manchester United's season on a high
Ferdinand's most recent problem was a calf strain that kept him on the sidelines for six weeks, since when he has been rested for another couple of games by Sir Alex Ferguson.
Indeed, it would be no surprise if the 32-year-old was omitted on Wednesday night, as United look to book a Champions League showdown with Barcelona at Wembley on May 28 by seeing off Schalke.
If he does, it will only be because he wants Ferdinand fresh, because the player himself is happy with his fitness just now.
What a pair: Defenders Rio Ferdinand (left) and Nemanja Vidic are key to the success of Manchester United
'People keep going on about how many games I have missed and compared to the usual amount I play you could say it has been a bit of a sporadic season for me,' Ferdinand told United Review.
'But I have been pleased with my performances and I feel back to my best now.
'My back is fine and hopefully I can put the niggling calf problems I have had this season behind me.
'I feel good and to be involved in the big games at this stage of the season, fighting for trophies, is what you want as a footballer. We just need to make sure we get the job done.'
Great expectations: Chris Smalling (left) is tipped for a bright future with Manchester United
If Ferdinand is left out, Chris Smalling is his likely replacement. The England Under 21 star has enjoyed an outstanding debut campaign following his arrival from Fulham and Ferdinand is convinced that in his fellow Londoner and Northern Ireland international Jonny Evans, United already have their defence of the future.
'Chris has been fantastic,' said Ferdinand. 'He and Jonny are great young players with big futures at this club. In time I am sure those two will be the bedrock of the team.'
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