Phil Jones is part of the Manchester United squad heading to Turkey, but Chris Smalling, Michael Carrick and Memphis Depay will miss the Europa League clash with Fenerbahce.
Jose Mourinho has named a 21-strong group as United continue their Group A campaign in Istanbul on Thursday evening.
Anthony Martial, Tim Fosu-Mensah and Henrikh Mkhitaryan have been included after missing recent squads, while Jones is part of the travelling squad 10 months after his last competitive appearance.
The 24-year-old has recovered from a knee injury but fellow defender Smalling, who has been suffering with a foot complaint recently, has remained in Manchester, as have the injured Antonio Valencia and Eric Bailly.
Carrick and Depay have also stayed in the north west and the reasoning behind Mourinho's squad selection should become clear at Wednesday's pre-match press conference.
Bastian Schweinsteiger is sure to be another topic of interest when the media convene at the Sukru Saracoglu Stadium.
The former Germany captain has returned to first-team training at United, but is not registered for the Europa League group stages.
United squad facing Fenerbahce: De Gea, Romero, Johnstone, Blind, Jones, Darmian, Fosu-Mensah, Rojo, Shaw, Fellaini, Herrera, Mkhitaryan, Lingard, Mata, Pogba, Schneiderlin, Young, Ibrahimovic, Martial, Rashford, Rooney
Source: PA
