The England international has not started for Sir Alex Ferguson's first team in the league since January because of a groin injury.
With United having stuttered of late in the league Ferguson could turn to the experienced Neville to fill his troublesome right-back role.
United are already without fellow right-backs Rafael da Silva and Wes Brown, while John O'Shea's confidence seems to have taken a pummelling after the club's back to back Premier League defeats.
Neville was on the bench for United's surprise defeat to Fulham prior to the international break and on Monday night played an hour at St James' Park as the club's second string drew with Newcastle 3-3.
Kiko Macheda was the game's outstanding performer as he netted a hat-trick for United.