Club record £30.75m signing Berbatov and free transfer arrival Owen netted their first goals of the season in last Saturday's 5-0 victory against Wigan at the DW Stadium.
Both forwards have struggled to hit their best form so far this term, but the pair are likely to face their toughest test of the campaign against Arsene Wenger's unbeaten Arsenal on Saturday.
Defender Ferdinand, currently out of action with a thigh injury, is confident that Berbatov and Owen will prove their worth once they are given the opportunity to show their credentials.
Ferdinand said: "People say certain things about Dimitar but he is always the first into training and the last to leave. He is a dedicated professional who wants to score goals for Manchester United.
"Maybe he is not like Wayne (Rooney) in the sense of being 100mph all the time. He is quite relaxed and does things in his own time.
"But you do not win the league with 11 players who are all the same.
"Michael has been hammered, yet he has not even played a full 90 minutes.
"People have said he was finished and was not worth the risk, yet he scored with probably his hardest chance of the season (against Wigan).
"I think that goal on Saturday will catapult him towards scoring a few more."
The performance at Wigan apart, United have been unconvincing as an attacking force since the £80m summer sale of Cristiano Ronaldo to Real Madrid.
Manager Sir Alex Ferguson has added just Owen, Antonio Valencia and Bordeaux winger Gabriel Obertan to his squad since Ronaldo's exit.
But despite reports in Spain linking United with a deadline move for Real's Arjen Robben, Ferdinand insists the club already have enough talent to prove they can be successful without Ronaldo.
He said: "The manager has so much intelligence and experience and he is not looking for a like-for-like replacement for Ronaldo. He wants players who can push the team further on.
"If we go into the season with what we have now I would sit very comfortably in our changing room.
"We have been successful in the last few years and we are not a one-man team."