Michael Owen could return from injury for the fourth-round tie against Mick McCarthy's side.
Owen resumed training after a groin injury last week and is set to return in a much-changed side after scoring twice in the 5-2 win at Scunthorpe in the last round.
Wayne Rooney will be out until next month with his ankle injury while Ryan Giggs (hamstring) and Jonny Evans (hip) are also sidelined.
Wolves have no new injury worries ahead of their trip to Old Trafford.
Ronald Zubar (ankle) and Jody Craddock (hip) are both out, while Michael Kightly has undergone an operation on his knee.
Stephen Hunt, who came off the bench against Chelsea, is in line for his first start of the season, while Karl Henry is still ineligible due to suspension.
Man Utd (from): Van der Sar, Kuszczak, O'Shea, Brown, Rafael, Neville, Ferdinand, Vidic, Smalling, Evra, Fabio, Nani, Obertan, Scholes, Fletcher, Carrick, Gibson, Anderson, Park, Giggs, Owen, Berbatov, Macheda, Hernandez.
Wolves (from): Hahnemann, Foley, Berra, Van Damme, Jarvis, Edwards, Jones, Ward, Fletcher, Ebanks-Blake, Doyle, Stearman, Mujangi Bia, Mouyokolo, Milijas, Elokobi, Hennessey, Hunt, Bent.