United are again without strikers Wayne Rooney and Michael Owen for visit of Spurs.
Rooney is resting an ankle problem which could keep him out for longer than the three weeks first feared while Owen suffered a hamstring injury in training this week. The former Liverpool forward is expected to be out for four to five weeks.
Veteran Ryan Giggs is also missing with a hamstring injury but should return to training on Monday. Jonny Evans could come back into contention after a hip injury.
Tottenham will once again be without Tom Huddlestone against the Red Devils.
The midfielder has failed to recover from the groin injury that forced him to miss last weekend's 1-1 draw with Everton.
Captain Ledley King and Vedran Corluka (both groin) are still out, while Jermain Defoe, Michael Dawson (both ligament damage), Jamie O'Hara (back) and Jonathan Woodgate (groin) are long-term absentees.
Kick-off at Old Trafford is 5:30pm.
United (from): Van der Sar, O'Shea, Brown, Rafael, Neville, Ferdinand, Vidic, Smalling, Evra, Evans, Fabio, Nani, Obertan, Scholes, Fletcher, Carrick, Gibson, Anderson, Park, Berbatov, Macheda, Hernandez, Kuszczak.
Spurs (from): Gomes, Cudicini, Hutton, Bale, Gallas, Bassong, Kaboul, Jenas, Sandro, Assou-Ekotto, Lennon, Palacios, Kranjcar, Bentley, Modric, Dos Santos, Crouch, Keane, Pavlyuchenko, Pletikosa.