The Scotland captain was sent off for two bookable offences at Birmingham last week and serves a one-match suspension.
Rio Ferdinand and Owen Hargreaves will not be considered despite edging their way closer to a return after long-term absences but Edwin van der Sar is expected to feature for the first time since November 21.
Team (from): Van der Sar, Kuszczak, Neville, Rafael, De Laet, Brown, Evans, Evra, Fabio, Valencia, Park, Carrick, Scholes, Anderson, Gibson, Giggs, Obertan, Rooney, Berbatov, Owen, Welbeck, Diouf.
Battler: Fletcher (right) will play no part against the Clarets
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