The duo missed the 1-1 home draw with Aston Villa last weekend with hamstring and hip problems respectively.
Dry season: Jerome has only scored four goals this term
Liam Ridgewell is again set to deputise at the heart of the defence for Scott Dann with David Murphy given another opportunity at left-back.
Dann will be out for the remainder of the season after undergoing surgery on his damaged hamstring.
Keeper Ben Foster will return to Old Trafford for the first time since his £6million summer move from United.
Team (from): Foster, Carr, Johnson, Ridgewell, Murphy, Bentley, Fahey, Ferguson, Gardner, Hleb, Derbyshire, Jerome, Larsson, Taylor, Bowyer, Phillips, Zigic, Beausejour, Mutch, Jiranek.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: David Murphy, Scott Dann, Ben Foster, Liam Ridgewell, Sebastian Larsson Places: Birmingham