Ferguson has a delicate selection poser following Sunday's 1-0 defeat at Arsenal.
With their lead over nearest challengers Chelsea cut to three points, United simply cannot afford to lose against Carlo Ancelotti's men at Old Trafford if they are to remain in charge of their own destiny.
However, they also have to defend a two-goal lead against Schalke on Wednesday night to book a meeting with Barcelona or Real Madrid at Wembley on May 28.
And Ferguson has already decided he must bring in some fresh faces in midweek.
"I will make some changes on Wednesday without question," said Ferguson.
"I will bring Paul Scholes back in, Dimitar Berbatov, Michael Owen.
"We'll need to do that but I will probably keep my experienced players at the back. We have a big week ahead.
"Wednesday is a European semi-final second leg and then the game on Sunday. Two massive games, so we will regroup and freshen it up."
Source: PA
