United are still in with a chance of a record fourth straight title but Ferguson knows the odds are stacked firmly against his team.
Apart from beating Stoke at Old Trafford, the Red Devils are also reliant on Wigan avoiding defeat at Chelsea, a feat that has only been achieved twice by any team this season.
"It's pointless going into the game expecting anything from Chelsea in our favour," said Ferguson.
"I have confidence that Wigan will do their best and they will try.
"There's pressure on both us and Chelsea because we both need to win but I don't know what's going on in Chelsea's minds - all I know is that in this situation we just hope. You never know.
"But I will find out what has happened because there are TV people standing in front of you, people beside you and the crowd reaction sometimes tells you,"
Ferguson will be without Antonio Valencia, who has been ruled out with an ankle injury, but Rio Ferdinand is expected to return.