United know that a win would all but end their bitter rivals' title challenge and set them on their way towards collecting their 11th title under the Scot.
Liverpool sit seven points behind United in third place having played a game more but will arrive at Old Trafford with their confidence sky high after their 4-0 hammering of Real Madrid in midweek.
Reds boss Rafa Benitez has never won at the Theatre of Dreams and his United counterpart will want to keep it that way.
"It's a Manchester Untied-Liverpool game nothing's going to change no matter what the hype is tomorrow," he told Sky Sports News.
"It doesn't make it any more intense than it normally is."
The United boss also added that he would be allowing his stars to go out and express themselves and insisted that his side are still improving.
"I'm not holding anyone back it's Manchester United-Liverpool," he added.
"It's not a time to hold back, it's a time to go forward and it's a time to enjoy it and keep expressing themselves the way they have been doing. Not getting afraid of the situation that's what this team have been doing for two or three years.
"Now it's a team full of optimism from my perspective and a team that have got great belief in themselves. They are young and they are getting better."