Manchester United, already winners of the Club World Cup this season, face Tottenham in the final of the Carling Cup on Sunday.
They are also chasing FA Cup glory but Ferguson concedes that his main concern is trying to repeat the domestic and European double from last season.
"We know what our priorities are," the Red Devils manager said ahead of this weekend's Wembley showpiece.
"As always, it is the Premier League and the Champions League. We have a game against Newcastle on Wednesday and that will be reflected in my team on Sunday."
Only place to beFerguson's side is expected to include a mix of senior, experienced players and youngsters who have played their part in the early rounds of the competition.
His opposite number Harry Redknapp will field the strongest XI available to him but Ferguson accepts that Tottenham will also be more interested in their final league position.
"The Premier League is the only place to be," said Ferguson.
"It is the only thing that matters - Harry Redknapp is well aware of that.
"Apart from the goalkeeper, the other 10 players that started last night will not do so again on Sunday.
"It is to do with how he can manage the next seven days. He has Middlesbrough on Wednesday and there is no doubt what is clear in Harry's mind - survival in the Premier League."