United know that they can end their rivals' title hopes with a win and go a step closer to securing their third successive Premier League crown.
Pride is also at stake for the visitors as they bid to defend their club's rich history. If United secure victory over Rafa Benitez's men and go on to win the league they will go level with Liverpool's title haul of 18.
Despite the derby with city rivals Manchester City and forging rivalries with title challengers Arsenal and Chelsea over the years, Ferguson is in no doubt that Liverpool remains the calendar's biggest fixture.
"Liverpool have always been our rival," he said.
"It does not matter what the position in the league, as far as I am concerned it has always been the derby game.
"It will always be that way because of the geography and history of the two cities.
Sparks"We are the two most successful football clubs in England. When they get together you expect sparks to fly."
With an average age of just 27 for their last league outing against Newcastle the former Aberdeen boss is confident that his squad can not only equal Liverpool's title record but surpass it.
"This team will win more league championships," he added.
"Whatever happens, this year is only part of the future which looks very good for our young players.
"There is evidence that we have a group that can stay together for quite a few years."
Ferguson, however, refused to be drawn on whether he thought the title would be over if his side were to win at the weekend.
"We have 10 games left so we must try and get a result and then look at the next nine," he explained.
"You do start to count down and eventually you run out of games. That is not psychology. It is about where you are in the league."