If Wayne Rooney is still struggling to find his best form in front of goal, the same cannot be said of Berbatov.
His third hat-trick of the season in Saturday's 5-0 mauling of Birmingham at Old Trafford emulated the feat of Ruud van Nistelrooy in the 2002-03 title-winning campaign.
Three and easy: Berbatov scores his third goal against Birmingham
And with a little more luck, he could have become the first player to score five twice in a single season since the new league was formed in 1992 such is his deadly streak.
It means Berbatov has now bagged 18 goals this season, by far his best tally since the club record £30.75million move from Tottenham in 2008.
'Dimitar is an amazing talent,' said O'Shea. 'We know if we get the supply line to him he will create things, either for himself and other players.
'Some of the passes he was laying off for Wayne and Nani were great. We just have to supply him because nine times out of 10 he will score.'
Not that Berbatov was on his own in ensuring United extended their unbeaten start to 22 games ahead of Tuesday's trip to Blackpool.
For a man who had been out since the end of November with a calf problem, O'Shea made a pretty fine return too. It was the Irishman who flicked Ryan Giggs' second-minute corner towards Berbatov to give the hosts their flying start.
'It has been a frustrating time,' he said. 'I thought it was only going to be a week to 10 days. But I pushed it a bit too soon and did it again. I had to be more careful after that.
'It is frustrating when you are missing games but I am delighted to be back.'
Back in action: John O'Shea challenges three Birmingham players at Old Trafford on Monday
Victory was enough to ensure United maintained top position, with Arsenal now leading the chasing pack, and Sir Alex Ferguson's men can now approach their first top flight visit to Blackpool in 40 years with an air of confidence.
And midfield dynamo Anderson is convinced about their title credentials, saying: 'We should definitely be considered favourites for the title.
'We are all happy with how things are going. We are top of the league, with games in hand. That is an amazing position.
'I know we haven't always played well but if we perform badly and still win the game then that is a good three points as far as I am concerned.
'It is nice to play attractive football but it is even better to win games.'
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Explore more:People: Wayne Rooney, Dimitar Berbatov, Alex Ferguson, John O'Shea, Ryan Giggs, Nani Places: Birmingham