Scholes has missed four games since suffering a groin injury during the Champions League win over Rangers and Sir Alex Ferguson does not expect to have the veteran midfielder back until the new year.
Experienced: Sir Alex Ferguson will have to make do without Scholes (right)
John O'Shea (calf) is also a doubt as United attempt to secure their first win at Stamford Bridge since 2002.
Team (from): Van der Sar, Kuszczak, Amos, Rafael, O'Shea, Neville, Ferdinand, Vidic, Smalling, Brown, Evans, Evra, Fabio, Nani, Park, Carrick, Anderson, Obertan, Giggs, Rooney, Berbatov, Hernandez, Macheda, Bebe.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: Paul Scholes, Alex Ferguson, Bebe, John O'Shea, Nani