Manchester United, Liverpool, Chelsea and Arsenal make up half of the sides left in it and can draw each other as Europe's premier club competition reaches a thrilling climax.
And we will be there to see events unfold at UEFA headquarters, where the line-up for the last eight and the semi-finals will be finalised.
You can see the draw live on Sky Sports News - and Sky Player
- and follow it here on skysports.com.
We will also bring you immediate reaction from the quartet of English clubs and their representatives out in Nyon, with Sky Sports News' Nick Collins mixing with the elite of English football.
Skysports.com will have reaction from the clubs as soon as the draw is made and will also give YOU the chance to tell us what you make of the draw.
Back in the Sky Sports News studio Ian Payne will also be joined by a panel of pundits to hear what they make of a draw that could see English sides pitted together at some stage before the competition's climax in Rome.
Defending champions Manchester United, 2005 winners Liverpool, last season's runners-up Chelsea and 2006 finalists Arsenal will be flying the flag for England and the Premier League.
But there is no shortage of talent representing the rest of Europe, not least in the shape of 2006 winners and La Liga leaders Barcelona.
Their Spanish rivals Villareal have been known to spring the odd Champions League surprise and will be considered dark horses, as will FC Porto, who of course lifted the trophy under Jose Mourinho in 2004.
And making up the last eight are none other than the might of Bayern Munich, who have been champions of Europe no fewer than four times.