Owen Coyle must decide whether to recall Jussi Jaaskelainen for the game as he returns from suspension.
Coyle has been impressed by the form of Adam Bogdan during Jaaskelainen's absence, although it would be a major surprise if the Finn was not recalled to face Sir Alex Ferguson's men.
Coyle is expected to revert to a full-strength line-up having made eight changes for the midweek Carling Cup defeat at Burnley - with Kevin Davies back from his ban to spearhead the Trotters attack. However, Gary Cahill serves the final game of a three-match suspension.
Sir Alex Ferguson is expected to ring the changes once more as the Red Devils make the short trip to face the Trotters.
The United boss selected a completely different starting line-up for the midweek Carling Cup triumph over Scunthorpe, which he missed to go on a Champions League scouting mission in Valencia, and it would be no surprise if only Rio Ferdinand kept his place at the Reebok Stadium.
Ferguson has reported an encouraging return to training for Owen Hargreaves after his knee problems, although the England star is not under consideration for Sunday's game and Michael Carrick (Achilles) is still sidelined.
Bolton (from): Jaaskelainen, Bogdan, Steinsson, Knight, Ricketts, Robinson, Alonso, Petrov, Taylor, Muamba, M Davies, Cohen, Holden, Moreno, Blake, Lee, K Davies, Elmander, Klasnic.
Man United (from): Van der Sar, Kuszczak, O'Shea, Neville, Rafael, Brown, Ferdinand, Vidic, Evans, Smalling, Evra, Fabio, Nani, Scholes, Fletcher, Gibson, Anderson, Park, Giggs, Berbatov, Rooney, Hernandez, Owen, Macheda.