The Brazilian full-back sat out Saturday's 5-0 win over Birmingham, so now Sir Alex Ferguson must decide whether to offer him instant recall or stick with John O'Shea, who played a key role in United's opener at Old Trafford.
In contention: Defender Rafael is free to return for United against Blackpool
Rio Ferdinand (groin) and Michael Carrick (ankle) are both doubts, but Ryan Giggs has already been promised a place for the Red Devils' first top-flight meeting with the Seasiders since 1971.
Team (from): Van der Sar, Kuszczak, Lindegaard, Rafael, O'Shea, Brown, Ferdinand, Vidic, Smalling, Evans, Evra, Fabio, Nani, Obertan, Carrick, Scholes, Fletcher, Gibson, Anderson, Giggs, Berbatov, Rooney, Hernandez, Owen, Bebe.
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Explore more:People: Alex Ferguson, Bebe, Rio Ferdinand, John O'Shea, Ryan Giggs, Nani, Michael Carrick Places: Birmingham