Manager Sir Alex Ferguson could be tempted to name the team that hammered Blackburn 7-1 after making 10 changes in midweek when they lost to West Ham in the Carling Cup.
Still going strong: But Scholes is set to miss out at Blackpool
Ryan Giggs and Darren Fletcher will both come into contention after recovering from their recent injuries.
Team (from): Van der Sar, Kuszczak, Rafael, O'Shea, Brown, Ferdinand, Vidic, Evans, Smalling, Evra, Fabio, Fletcher Nani, Park, Carrick, Scholes, Anderson, Obertan, Giggs, Rooney, Berbatov, Hernandez, Macheda, Bebe.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: Paul Scholes, Alex Ferguson, Darren Fletcher, Bebe, Ryan Giggs