With Nemanja Vidic (leg) joining Rio Ferdinand (back) on the sidelines, Sir Alex Ferguson will turn to the duo even though they were at the heart of a defence breached by Leeds last Sunday.
Case for the defence: Brown (right) and Evans (left) should take their places
Paul Scholes (hip) is fit, while new arrival Mame Biram Diouf has gained clearance to play and, having been allocated Carlos Tevez's old shirt number (32), could be involved.
Team (from): Kuszczak, Foster, Neville, Rafael, De Laet, Brown, Evra, Fabio, Valencia, Park, Carrick, Fletcher, Scholes, Anderson, Gibson, Giggs, Obertan, Rooney, Berbatov, Owen, Welbeck, Diouf, Tosic.
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