The Portugal winger missed Sunday's win over Sunderland with a hip complaint but is set to come back into a United line-up Ferguson intends to change in order to keep it fresh.
Winging his way back in: Nani (left) should be in the United team at Birmingham
Park Ji-sung has now left for his Asian Cup commitments with South Korea and Paul Scholes (groin) is also out, while there are doubts over John O'Shea (calf) and Darren Fletcher, who was sent home from training on Christmas Day with a heavy cold.
Team (from): Van der Sar, Kuszczak, Rafael, Brown, Neville, O'Shea, Ferdinand, Vidic, Smalling, Evans, Evra, Fabio, Nani, Obertan, Carrick, Fletcher, Gibson, Anderson, Giggs, Bebe, Rooney, Berbatov, Macheda, Hernandez, Owen.
CLICK HERE FOR THE REST OF THE MIDWEEK BARCLAYS PREMIER LEAGUE TEAM NEWS Explore more:People: Alex Ferguson, Paul Scholes, Darren Fletcher, John O'Shea, Park Ji-sung, Bebe, Nani Places: Birmingham, South Korea, Portugal