The Bulgarian wrapped up a 3-0 win for the Red Devils over Fulham following two more goals from Wayne Rooney that took his amazing tally to 32.
It took United two points clear of Chelsea and Arsenal in what is turning into a fascinating title race given Carlo Ancelotti's men have a game in hand, with all three sides boasting very similar goal differences.
Celebration time: Berbatov is congratulated by Nani as United seal another victory
Yet Berbatov is confident the ultimate domestic prize will end up atOld Trafford, just as it did in his first season following a clubrecord £30.75million move from Tottenham.
'There can only be one winner and I think it is going to be us,' said Berbatov.
'Arsenaland Chelsea are great teams and we have difficult games ahead of us butthe good thing is we play at home at Old Trafford against Chelsea andthat will be an advantage for us.
'I am optimistic that in the end we will be champions.'
Althoughhis manager doubtless hopes Berbatov is correct, Sir Alex Ferguson hasbeen involved in enough of these scraps to know this one looks amongthe mostintriguing, with Arsenal looking to have the easier run-in,even though United and Chelsea both know if they win all their games,including the crunch meeting between the pair at Old Trafford on April3, they cannot be caught.
'At the moment it is looking like the tightest Premier League we have had,' said the United chief.
Heads up: Berbatov heads home United's third goal against Fulham
'It is very tight. We only have eight games left. Chelsea have nine. We are all involved in Europe. Chelsea also have the FA Cup.
'I suppose the simple way for us and Chelsea to look at it is just to win all our games. But life is never that simple.'
United will feel they have a good chance as long as Rooney stays fit. It took him just 29 seconds of the second-half to break the deadlock and it was Rooney's goal seven minutes from time that settled home nerves after the Red Devils had spurned a succession of chances.
The 24-year-old is now just 10 goals adrift of the mammoth number Cristiano Ronaldo scored two seasons ago, although Rooney would prefer to avoid the comparison.
'If I am being honest, getting to 42 goals wouldn't mean a lot to me,' he said. 'It is not something I have looked at.
'Obviously it is nice to score goals. I want to score goals in every game and what Cristiano Ronaldo achieved was unbelievable.
'But I am a different player and a different person. I am not comparing myself to Cristiano.'
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