Aside from two drawn matches in the group stage of the same season's competition, Bayern have emerged victorious on two occasions, one of which was due to a crucial away goal at Old Trafford.
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"A score draw or win is all you can hope for," Ferguson said.
"It would give us a good chance."
It is the same philosophy that served United so well in Milan for the last round, when despite falling behind to Ronaldinho's early goal, they maintained an attacking mentality and ultimately scored three times to put the tie well beyond David Beckham and his team-mates even before they were massacred at Old Trafford.
"We would like to equal our performance in Milan," he said.
"If we get the same kind of performance and result we would have a massive advantage coming back to Old Trafford."
United will encounter a different team, which relies on the pace of wing duo Franck Ribery and Arjen Robben.
Both men are well known to Ferguson given he has looked often enough at the former, especially in the wake of Cristiano Ronaldo's departure, and thought he had got the latter until Chelsea stepped in to snap him up in 2004.
Although Bastian Schweinsteiger is suspended, with the likes of Mark van Bommel, Philipp Lahm and Miroslav Klose in their squad, Bayern are not opponents Ferguson intends to take lightly.
"The history of Bayern and our games against them in past European ties tells you it is going to be a very difficult game," said Ferguson.
"It will be a fantastic atmosphere, in a great stadium, with a good pitch.
"They are an experienced team. But hopefully we get everyone we need fit and we will have a good chance."