The Rome-born midfielder has attracted interest across Europe, with Manchester City and Real Madrid the most strongly linked.
"Daniele will remain at Roma forever, Real can forget about him," Sensi said to Il Messaggero.
The 26-year-old has been linked with moves away from the club before.
Last summer, Real were keen to acquire De Rossi's services but the Eternal City outfit opted to keep the player who is contracted until June 2012.
The Italian press believe Real are back in the race to sign De Rossi, one of the players Jose Mourinho wants to take with him to Madrid if the Portuguese manager completes his expected move to Spain.
De Rossi, who is currently training with Italy in preparation for next month's World Cup said: "I don't know anything about Real's interest.
"To be linked with important clubs makes me happy because it's a sign that I'm doing things well.
"I would consider a move away only if the club tells me that for technical, tactical or financial reasons they must sell me.
"Would I have any problems working with (Jose) Mourinho? Absolutely not."
Meanwhile, Roma coach Claudio Ranieri has confirmed his club are closing in on the free-transfer signing of Brazil forward Adriano.
The former Inter Milan player is expected to return to Europe this summer, with Roma favourites to land the 28-year-old.
When asked about Adriano, Ranieri said: "Adriano is our bet, I'm not sure if it will be a winning one but it is a gamble."
Reports in Italy claim Adriano met with Roma sporting director Daniele Prade in Brazil yesterday to finalise a move to the capital club.
Adriano signed a one-year deal with Flamengo in May 2009, one month after his contract with Inter was terminated.