Robinho limped out of Saturday's 2-0 defeat at Portsmouth with a tight thigh and will now have treatment in the hope he can make the trip to Denmark for the first leg of the last 32 clash.
Blue mood: Robinho (left) rests with an ice-pack on his right thigh after limping off during Manchester City's 2-0 defeat at Portsmouth on Saturday.
'Robinho has a bit of tightness at the top of his thigh but he should be OK,' Hughes told BBC Radio Manchester.
As Darius Vassell missed Saturday's lacklustre performance on the south coast with an illness, Hughes needs Robinho fit, otherwise he could be short of forward players.
Benjani Mwaruwari and Danny Sturridge have already been ruled out, which could leave Craig Bellamy, Felipe Caicedo and Ched Evans as his only available front men.
England defender Micah Richards is also facing a fitness test on the ankle injury which kept him out at the weekend after it initially failed to respond to treatment.
On the brighter side, Hughes is able to welcome back Shaun Wright-Phillips and skipper Richard Dunne from domestic suspensions.
However, new signing Nigel de Jong will miss out, having been overlooked in favour of Bellamy, Wayne Bridge and Shay Given when Hughes made his three permitted changes to his European squad in January.
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